Your inner fish notes- turn in.
Finish evidence for evolution- student presentation
HHMI- The Making of the Fittest: Evolving Switches, Evolving Bodies - see video of investigation -posted below
- complete packet (pages 1-7) due tomorrow BOP
KEY CONCEPTS AND LEARNING OBJECTIVES- Evolving Switches, evolving bodies.
• Virtually all cells in the body have the same genetic makeup,* but not all genes are expressed in all tissues at all times.
• Whether a gene is expressed is dependent on the regulatory switches that the gene possesses and the activators or repressor proteins present in that cell.
• Activators bind to regulatory switches in a sequence-specific manner. The binding of the activators to the switches activates transcription.
• Some genes, especially genes involved in body development, have multiple switches. Each switch independently regulates the expression of the gene in different parts of the body at different times in the animal’s life cycle.
• The presence of multiple switches enables the same gene to be used many times in different contexts and thus greatly expand the functional versatility of individual genes.
• Mutations in regulatory switches affect expression of a particular gene in a particular tissue without affecting the gene’s protein product (shape and function).
• Changing the expression of a gene involved in body development can have profound effects in shaping the body.
(* There are some notable exceptions: (1) Mature red blood cells have no DNA. (2) Germ line cells (sperm and egg) have half the genetic material. (3) B cells, which are part of the immune system, have DNA that has been rearranged to make antibodies. (4) Cells acquire somatic mutations. In some cases, these mutations confer a selective advantage for that cell and that mutation will be fixed in a set population of cells, like in the case of cancer cells. )
At the end of this activity, you should be able to:
• Correctly interpret visual representations of eukaryotic gene transcription.
• Contrast how mutations in regulatory switches differ from mutations in coding regions of genes.
Great Animation for understanding gene regulation:
HW: Read Investigation 3 (AP Biology Lab manual)- page 41:Comparing DNA Sequences to Understand Evolutionary Relationships with BLAST.
- Complete Getting started elements 1-2 on page 43.- Use your own sheet of cellulose: Due tomorrow BOP.
HHMI- The Making of the Fittest: Evolving Switches, Evolving Bodies
- get packet checked off and correct with key posted today.
- HW: Show evidence of corrections with diffrent colored ink.- If you have any questions ask. You will need to demonstrate your understand this later. Hint...hint...:) Turn in Wednesday BOP
The Evolution of Flight in Birds-
Complete steps 1-5 (including special assignment)-
The goal of this assignment is to develop a logical, well-supported hypothesis about how and when flight evolved in the dinosaur lineage
- Based on the evidence at hand, develop a hypothesis about the evolution of flight. If possible, this hypothesis should describe both the "how" and the "when."
- Present your written hypothesis to another student for review- have them sign that you did this...
Check in - gene switches and evolution-
HW: complete 2015 FRQ- phylogenetic tree- due tomorrow BOP.
Comparing DNA Sequences to Understand Evolutionary Relationships with BLAST.
Go through BLAST procedure- pg. 45
- Basic Local Alignment Search Tool: http://blast.ncbi.nlm.nih.gov/Blast.cgi
- A portal to gene-specific content based on NCBI's RefSeq project, information from model organism databases, and links to other resources.www.ncbi.nlm.nih.gov/gene/
- The three files you will use for the gene sequences are found below.
- answer all questions for the "Analyzing Results " section- pg. 48
- read/answer "Evaluating Results" section- page 49
- Read/answer "Designing and Conducting Your Investigation" section- page 49-50. Investigate one gene of interest- answer framing questions for this part.
Due Monday BOP
Score FRQ. / Peer score, Complete reflection - include what you would need to to get a perfect score. Due Mon. BOP.
Science Elective Course Offerings- presentations
Continue with BLAST investigation - due Monday BOP (Analyzing results and Evaluating Results sections.
Select one gene of interest to you and use BLAST to investigate some of the questions you have about this gene. Complete this in Google Classroom- "BLAST investigation reflection"
Chapter review deadline moved to Monday- BOP, +3 e.c. if completed tomorrow- see me to have stamped off.